Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.82 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796744 | 0.89 | PDE3B (0.82) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796659 | 0.87 | PDE3B (0.80) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796719 | 0.85 | PDE3B (0.76) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796664 | 0.84 | PDE3B (0.74) | PDE3BPDE3AIDH1KDM4EHPGD | |
| SCHEMBL18796774 | 0.82 | PDE3B (0.71) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796726 | 0.81 | PDE3B (0.70) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796756 | 0.81 | PDE3B (0.73) | PDE3BPDE3AKDM4EHPGDGALR3 | |
| SCHEMBL18796800 | 0.80 | PDE3B (0.68) | PDE3BPDE3AIDH1KDM4EDAO | |
| SCHEMBL18796777 | 0.79 | PDE3B (0.66) | PDE3BPDE3AIDH1KDM4EHPGD | |
| SCHEMBL18796709 | 0.79 | PDE3B (0.66) | PDE3BPDE3AKDM4EHPGDGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |