Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.82 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796728 | 0.88 | PDE3B (0.82) | PDE3BPDE3APTGESALOX5MDM2 | |
| SCHEMBL18796736 | 0.86 | PDE3B (0.77) | PDE3BPDE3APTGESALOX5KDM4E | |
| SCHEMBL18796711 | 0.85 | PDE3B (0.77) | PDE3BPDE3APTGESMDM2KDM4E | |
| SCHEMBL18796695 | 0.84 | PDE3B (0.76) | PDE3BPDE3AMDM2KDM4EMAPT | |
| SCHEMBL18796626 | 0.83 | PDE3B (0.78) | PDE3BPDE3APTGESALOX5MDM2 | |
| SCHEMBL18796629 | 0.83 | PDE3B (0.85) | PDE3BPDE3AALOX5MDM2KDM4E | |
| SCHEMBL18796716 | 0.80 | PDE3B (0.80) | PDE3BPDE3AMDM2KDM4EMAPT | |
| SCHEMBL18796782 | 0.80 | PDE3B (0.80) | PDE3BPDE3AALOX5MDM2KDM4E | |
| SCHEMBL18819730 | 0.80 | PDE3B (0.76) | PDE3BPDE3AMDM2KDM4EMAPT | |
| SCHEMBL18796742 | 0.80 | PDE3B (0.76) | PDE3BPDE3AMDM2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |