Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.58 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383880 | 0.87 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383545 | 0.87 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL3380967 | 0.86 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL384267 | 0.86 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL14223108 | 0.86 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383696 | 0.85 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL382952 | 0.85 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383822 | 0.85 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL382815 | 0.85 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383403 | 0.83 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883790-B2 | Pharmaceutical combinations | ASTEX THERAPEUTICS LIMITED (GB) | 2014-11-11 | — | — | US | disclosed |
| US-20110105501-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105501-A1 | PHARMACEUTICAL COMBINATIONS | GSK3B, CDK1, GSK3A | HSP90AA1 105/4885HSP90AB1 49/4885HDAC8 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.