Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 1.00 |
| ▸ | MAPK12 | P53778 | 9/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 9/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 9/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770288 | 1.00 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL20555598 | 1.00 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| Bromide SCHEMBL5770111 | 0.98 | MAPK13 (0.97) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| Hydrochloric Acid SCHEMBL5768856 | 0.98 | MAPK13 (0.97) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5772040 | 0.96 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL29437788 | 0.96 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5767876 | 0.93 | MAPK13 (0.87) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5770557 | 0.92 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5771142 | 0.91 | MAPK13 (0.84) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5772600 | 0.90 | MAPK11 (0.82) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368052-A1 | USE OF MAPK INHIBITORS TO REDUCE LOSS OF HEMATOPOIETIC STEM CELLS DURING EX VIVO CULTURE AND/OR GENETIC MANIPULATION | Children's Hospital Medical Center (US) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017075274-A1 | USE OF MAPK INHIBITORS TO REDUCE LOSS OF HEMATOPOIETIC STEM CELLS DURING EX VIVO CULTURE AND/OR GENETIC MANIPULATION | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2017-05-04 | — | — | WO | disclosed |