Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.49 |
| ▸ | EED | O75530 | 3/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.40 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.40 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12684097 | 0.86 | EZH2 (0.56) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL21418319 | 0.83 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12683928 | 0.82 | EZH2 (0.73) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170042 | 0.81 | EZH2 (0.63) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL21418328 | 0.77 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684331 | 0.75 | EZH2 (0.61) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12683973 | 0.74 | EZH2 (0.63) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19958898 | 0.74 | EZH2 (0.54) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL15490723 | 0.74 | EZH2 (0.86) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499854 | 0.74 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |