Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.75 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | EED | O75530 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.52 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499612 | 0.91 | EZH2 (0.76) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL30386468 | 0.91 | EZH2 (0.76) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL12683939 | 0.89 | EZH2 (0.73) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL12499470 | 0.85 | EZH2 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL15490872 | 0.84 | EZH2 (0.80) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL20170343 | 0.80 | EZH2 (0.63) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL10255708 | 0.80 | EZH2 (0.68) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL15490723 | 0.78 | EZH2 (0.86) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12684246 | 0.78 | EZH2 (0.86) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17732385 | 0.78 | EZH2 (0.87) | EZH2EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |