Known targets — ChEMBL curated mechanism
CSF1RFLT1FLT3FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Linifanib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 19/20 | 0.98 |
| ▸ | FLT3 known ✓ | P36888 | 16/20 | 0.98 |
| ▸ | CSF1R known ✓ | P07333 | 10/20 | 0.98 |
| ▸ | FLT4 known ✓ | P35916 | 10/20 | 0.98 |
| ▸ | FLT1 known ✓ | P17948 | 9/20 | 0.98 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.98 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 0.98 |
| ▸ | KIT | P10721 | 14/20 | 0.98 |
| ▸ | LYN | P07948 | 7/20 | 0.98 |
| ▸ | SRC | P12931 | 6/20 | 0.98 |
| ▸ | BLK | P51451 | 6/20 | 0.98 |
| ▸ | AURKA | O14965 | 5/20 | 0.98 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.98 |
| ▸ | PLK4 | O00444 | 4/20 | 0.98 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.98 |
| ▸ | MET | P08581 | 4/20 | 0.98 |
| ▸ | PRKACA | P17612 | 4/20 | 0.98 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.98 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.98 |
| ▸ | STK3 | Q13188 | 4/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Linifanib SCHEMBL29375368 | 0.99 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL93804 | 0.99 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL2239943 | 0.96 | KDR (0.94) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL421934 | 0.90 | KDR (0.82) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL420765 | 0.89 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL1662335 | 0.89 | KDR (0.81) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL423705 | 0.88 | KDR (0.80) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL424019 | 0.88 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL1659063 | 0.88 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL6073436 | 0.88 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759538-B1 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2014-06-24 | — | — | US | claimed |
| EP-2195298-B1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | ABBVIE BAHAMAS LTD (BS) | 2014-02-19 | — | — | EP | claimed |
| US-8486988-B2 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2013-07-16 | — | — | US | claimed |
| US-20110196010-A1 | CRYSTALLINE CHEMOTHERAPEUTIC | ABBOTT LABORATORIES (US) | 2011-08-11 | — | — | US | claimed |
| US-7947843-B2 | Crystalline chemotherapeutic | ABBOTT LABORATORIES (US) | 2011-05-24 | — | — | US | claimed |
| EP-2195298-A1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | Abbott Laboratories (US) | 2010-06-16 | — | — | EP | claimed |
| US-20090118344-A1 | Crystalline Chemotherapeutic | ABBOTT LABORATORIES (US) | 2009-05-07 | — | — | US | claimed |
| WO-2009052226-A1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | WO | claimed |
| US-8759538-B1 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759538-B1 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2014-06-24 | — | — | US | disclosed |
| EP-2195298-B1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | ABBVIE BAHAMAS LTD (BS) | 2014-02-19 | — | — | EP | disclosed |
| US-8486988-B2 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486988-B2 | Crystalline chemotherapeutic | ABBVIE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| CN-101827822-B | Crystalline indazole-derived chemotherepeutic | ABBOTT LAB | 2013-06-19 | — | — | CN | disclosed |
| US-20090124816-A1 | Crystalline Chemotherapeutic | ABBOTT LABORATORIES (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090118344-A1 | Crystalline Chemotherapeutic | ABBOTT LABORATORIES (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118344-A1 | Crystalline Chemotherapeutic | ABBOTT LABORATORIES (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009052226-A1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009052226-A1 | CRYSTALLINE INDAZOLE-DERIVED CHEMOTHEREPEUTIC | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009052231-A1 | CRYSTALLINE CHEMOTHERAPEUTIC | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | WO | disclosed |