Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 13/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12684176 | 0.87 | EZH2 (0.53) | PDE9AEZH2 | |
| SCHEMBL18800367 | 0.78 | EZH2 (0.59) | PDE9AEZH2 | |
| SCHEMBL12499856 | 0.72 | EZH2 (0.72) | EZH2 | |
| SCHEMBL12684276 | 0.71 | EZH2 (0.59) | PDE9AEZH2 | |
| SCHEMBL12684088 | 0.70 | EZH2 (0.51) | PDE9AEZH2 | |
| SCHEMBL18800336 | 0.69 | EZH2 (0.70) | EZH2 | |
| SCHEMBL20170053 | 0.69 | ADORA1 (0.36) | — | |
| SCHEMBL25542823 | 0.68 | AKR1C4 (0.35) | EZH2 | |
| SCHEMBL21418348 | 0.68 | EZH2 (0.64) | EZH2 | |
| SCHEMBL21418341 | 0.67 | EZH2 (0.56) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |