Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6115775 | 0.90 | BTK (0.89) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL1162679 | 0.88 | BTK (0.87) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL1163040 | 0.86 | BTK (0.65) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL8402016 | 0.84 | BTK (1.00) | BTK | |
| SCHEMBL6116414 | 0.84 | BTK (1.00) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL8401927 | 0.84 | BTK (0.80) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL6116297 | 0.84 | BTK (0.80) | BTK | |
| SCHEMBL6116511 | 0.83 | BTK (0.77) | BTKPIK3CDNUDT14PIK3CAPIK3CB | |
| SCHEMBL6115741 | 0.83 | BTK (0.78) | BTK | |
| SCHEMBL16161557 | 0.83 | BTK (0.78) | BTKPIK3CDNUDT14PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |