Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.51 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800912 | 0.96 | PARP14 (0.51) | BTKPARP14PARP10MAP3K12EGFR | |
| SCHEMBL18800410 | 0.88 | BTK (0.67) | BTKEGFRTEC | |
| SCHEMBL18800675 | 0.86 | BTK (0.49) | BTKEGFRTEC | |
| SCHEMBL18800819 | 0.86 | BTK (0.48) | BTKEGFRTEC | |
| SCHEMBL18800810 | 0.82 | BTK (0.45) | BTKEGFRTEC | |
| SCHEMBL6115602 | 0.80 | BTK (0.79) | BTKPARP14PARP10MAP3K12 | |
| SCHEMBL18800814 | 0.79 | BTK (0.66) | BTKEGFRTEC | |
| SCHEMBL18800807 | 0.79 | ATR (0.48) | BTK | |
| SCHEMBL18800694 | 0.78 | BTK (0.47) | BTK | |
| SCHEMBL16168187 | 0.78 | BTK (0.47) | BTKEGFRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |