Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.45 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.44 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | LPL | P06858 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.43 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1880075 | 1.00 | SPHK2 (0.52) | SPHK2SPHK1SMPD1PRKD1MAP1LC3B | |
| SCHEMBL1878644 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL1878645 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL1875631 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL1880385 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL1875630 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL1880381 | 0.85 | ASAH2 (0.57) | SPHK2SPHK1ASAH2 | |
| SCHEMBL2763884 | 0.82 | SPHK2 (0.54) | SPHK2SPHK1SMPD1MAP1LC3BMAP1LC3A | |
| SCHEMBL13323770 | 0.81 | SPHK2 (0.52) | SPHK2SPHK1SMPD1MAP1LC3BMAP1LC3A | |
| SCHEMBL12638356 | 0.81 | SPHK2 (0.57) | SPHK2SPHK1SMPD1MAP1LC3BMAP1LC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | SPHK2, SPHK1, S1PR2 | SPHK2 1/4885SPHK1 2/4885SMPD1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.