Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 14/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GCK | P35557 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18906 | 0.93 | GCKR (0.60) | GCKRJAK2MAPTGCK | |
| SCHEMBL18922 | 0.91 | GCKR (0.57) | GCKRJAK2MAPTGCK | |
| SCHEMBL12089640 | 0.89 | GCKR (0.68) | GCKRGCK | |
| SCHEMBL18608 | 0.87 | GCKR (0.76) | GCKRJAK2MAPTGCK | |
| SCHEMBL18752 | 0.87 | GCKR (0.76) | GCKRJAK2MAPTGCK | |
| SCHEMBL12077871 | 0.87 | GCKR (0.79) | GCKRGCK | |
| SCHEMBL16159 | 0.87 | GCKR (0.79) | GCKRGCK | |
| SCHEMBL18800 | 0.87 | GCKR (0.79) | GCKRGCK | |
| SCHEMBL17667 | 0.85 | GCKR (0.61) | GCKRGCK | |
| SCHEMBL18090 | 0.83 | GCKR (0.76) | GCKRJAK2MAPTGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |