Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692233 | 0.92 | SMN1; SMN2 (0.70) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14219228 | 0.89 | TDP1 (0.72) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12446326 | 0.89 | TDP1 (0.72) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL31657266 | 0.89 | TDP1 (0.72) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19643833 | 0.88 | TDP1 (0.70) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL6022193 | 0.86 | TDP1 (0.68) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9574171 | 0.86 | TDP1 (0.68) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4850239 | 0.86 | TDP1 (0.68) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL13997917 | 0.86 | TDP1 (0.72) | TDP1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1788501 | 0.85 | MAPT (0.72) | TDP1HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170119899-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOMAL DISORDERS AND LEUKODYSTROPHIES | THE JOHNS HOPKINS UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
| US-20170119899-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOMAL DISORDERS AND LEUKODYSTROPHIES | THE JOHNS HOPKINS UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170119899-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOMAL DISORDERS AND LEUKODYSTROPHIES | CLN6, PEX3, GBA1 | TDP1 504/4885HDAC3 1371/4885HDAC1 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.