Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121372 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL21442993 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL19489056 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL19489058 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL22109210 | 0.81 | EPHX1 (0.36) | KDM4ETP53SMN1; SMN2MAPTGMNN | |
| SCHEMBL24754269 | 0.80 | EPHX1 (0.36) | KDM4EEPHX1EPHX2 | |
| SCHEMBL15099936 | 0.78 | TP53 (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL27992126 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL11461186 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL25474390 | 0.74 | TP53 (0.41) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167489-B1 | PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2017-05-03 | — | — | EP | disclosed |