SCHEMBL1881111

SCHEMBL1881111

O=C(O)C#Cc1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19151706 0.97
SCHEMBL19151707 0.90
SCHEMBL19131166 0.84
SCHEMBL776450 0.75
SCHEMBL30940474 0.70
SCHEMBL10300045 0.69
SCHEMBL19433659 0.68
SCHEMBL19151796 0.68 MEN1 (0.32)
Lithium SCHEMBL30940470 0.68
SCHEMBL30940476 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1982988-B1 METHOD OF SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUNDS USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B JAPAN SCIENCE & TECH AGENCY (JP) 2014-06-04 EP claimed
US-7939679-B2 Method for synthesis of ciguatoxin CTX1B and compounds useful for the synthesis of ciguatoxin CTX1B JAPAN SCIENCE & TECHNOLOGY AGENCY (JP) 2011-05-10 US claimed
US-20100160651-A1 METHOD FOR SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUNDS USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2010-06-24 US claimed
EP-1982988-A1 METHOD FOR SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUND USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B Japan Science and Technology Agency (JP) 2008-10-22 EP claimed
WO-2024019014-A1 RADIOLABELED ACTIVATED ESTER AND PRECURSOR THEREOF 国立大学法人東京工業大学 2024-01-25 WO disclosed
EP-1982988-B1 METHOD OF SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUNDS USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B JAPAN SCIENCE & TECH AGENCY (JP) 2014-06-04 EP disclosed
US-7939679-B2 Method for synthesis of ciguatoxin CTX1B and compounds useful for the synthesis of ciguatoxin CTX1B JAPAN SCIENCE & TECHNOLOGY AGENCY (JP) 2011-05-10 US disclosed
US-20100160651-A1 METHOD FOR SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUNDS USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2010-06-24 US disclosed
EP-1982988-A1 METHOD FOR SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUND USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B Japan Science and Technology Agency (JP) 2008-10-22 EP disclosed