Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.55 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16022201 | 0.88 | MAPK6 (0.62) | MAPK6GSK3AGSK3BSYKPDE4B | |
| Carbamic Acid SCHEMBL18813077 | 0.86 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKACCNA2 | |
| Carbamic Acid SCHEMBL18813123 | 0.84 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKACCNA2 | |
| Carbamic Acid SCHEMBL18813125 | 0.84 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKACCNA2 | |
| Carbamic Acid SCHEMBL18813174 | 0.83 | MAPK6 (0.56) | MAPK6GSK3AGSK3BAURKACCNA2 | |
| Carbamic Acid SCHEMBL18813041 | 0.83 | MAPK6 (0.56) | MAPK6GSK3AGSK3BSYKAURKA | |
| Carbamic Acid SCHEMBL18813026 | 0.83 | GSK3A (0.56) | MAPK6GSK3AGSK3BSYK | |
| Carbamic Acid SCHEMBL18813046 | 0.82 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKAMAPK8 | |
| Carbamic Acid SCHEMBL18813052 | 0.82 | MAPK6 (0.63) | MAPK6GSK3AGSK3BAURKACCNA2 | |
| Carbamic Acid SCHEMBL18813033 | 0.82 | MAPK6 (0.54) | MAPK6GSK3AGSK3BAURKACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |