Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 13/20 | 0.71 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18813038 | 0.88 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL18813116 | 0.88 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012457 | 0.88 | MAPK6 (0.73) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012187 | 0.88 | MAPK6 (0.73) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16022221 | 0.85 | MAPK6 (0.74) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18813109 | 0.84 | MAPK6 (0.51) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| Carbamic Acid SCHEMBL18813032 | 0.84 | MAPK6 (0.81) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| Carbamic Acid SCHEMBL18813103 | 0.84 | MAPK6 (0.81) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL18813098 | 0.84 | MAPK6 (0.60) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL18813055 | 0.84 | MAPK6 (0.60) | MAPK6GSK3AGSK3BEIF2AK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |