Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | BCL6 | P41182 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830274 | 0.94 | MAPK6 (0.60) | MAPK6GSK3AGSK3BPDE4BPDE4D | |
| Carbamic Acid SCHEMBL18813100 | 0.92 | MAPK6 (0.57) | MAPK6GSK3AGSK3BMAPK8ADORA2A | |
| Carbamic Acid SCHEMBL18813057 | 0.90 | MAPK6 (0.64) | MAPK6GSK3AGSK3BPDE4BPDE4D | |
| Carbamic Acid SCHEMBL18813069 | 0.89 | MAPK6 (0.59) | MAPK6GSK3AGSK3BMAPK8AURKA | |
| SCHEMBL16022218 | 0.88 | MAPK6 (0.71) | MAPK6GSK3AGSK3BPDE4BPDE4D | |
| Carbamic Acid SCHEMBL18813032 | 0.86 | MAPK6 (0.81) | MAPK6GSK3AGSK3BAURKACDK2 | |
| SCHEMBL18830106 | 0.85 | MAPK6 (0.53) | MAPK6GSK3AGSK3BMAPK8ADORA2A | |
| Carbamic Acid SCHEMBL18813068 | 0.85 | MAPK6 (0.80) | MAPK6GSK3AGSK3BAURKACDK2 | |
| Carbamic Acid SCHEMBL18813058 | 0.84 | MAPK6 (0.65) | MAPK6GSK3AGSK3BMAPK8AURKA | |
| Carbamic Acid SCHEMBL18813043 | 0.84 | MAPK6 (0.60) | MAPK6GSK3AGSK3BAURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |