Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25574538 | 0.88 | MAPT (0.67) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL30378007 | 0.88 | MAPT (0.67) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL20078108 | 0.86 | DDB1 (0.53) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL17184636 | 0.85 | DDB1 (0.53) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL15875047 | 0.85 | DDB1 (0.53) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL11929937 | 0.85 | DDB1 (0.55) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL18570958 | 0.85 | DDB1 (0.53) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL740206 | 0.84 | DDB1 (0.53) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL13028051 | 0.84 | DDB1 (0.52) | DDB1CRBNMAPTNR1H2ESR2 | |
| SCHEMBL741949 | 0.83 | CCNA2 (0.53) | DDB1CRBNMAPTNR1H2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428762-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2017071636-A1 | PHTHALAZINE KETONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-05-04 | — | — | WO | disclosed |