Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GPR183 | P32249 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
| ▸ | ITGAL | P20701 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845314 | 0.81 | CA12 (0.53) | ALDH1A1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL4055672 | 0.81 | CA12 (0.53) | ALDH1A1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL4055668 | 0.81 | CA12 (0.53) | ALDH1A1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL1580033 | 0.80 | POLB (0.79) | GAAPOLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL1580034 | 0.80 | POLB (0.79) | GAAPOLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL1580935 | 0.79 | GAA (0.73) | GAAPOLBALDH1A1MAPTKDM4E | |
| SCHEMBL14610112 | 0.78 | POLB (1.00) | GAAPOLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL16599097 | 0.77 | GPR183 (0.62) | GPR183 | |
| SCHEMBL16598923 | 0.77 | GPR183 (0.62) | GPR183 | |
| SCHEMBL1579608 | 0.77 | GAA (0.71) | GAAPOLBALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC S.R.L. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | HDAC3, HDAC1, HDAC5 | GAA 3622/4885POLB 650/4885ALDH1A1 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.