Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.81 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796715 | 0.90 | PDE3B (0.78) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796724 | 0.89 | PDE3B (0.76) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796790 | 0.88 | PDE3B (0.74) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796656 | 0.87 | PDE3B (0.73) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796689 | 0.87 | PDE3B (0.73) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796638 | 0.86 | PDE3B (0.79) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796672 | 0.85 | PDE3B (0.73) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796661 | 0.83 | PDE3B (0.67) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796736 | 0.82 | PDE3B (0.77) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL18796658 | 0.82 | PDE3B (0.76) | PDE3BPDE3AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |