Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.70 |
| ▸ | MLYCD | O95822 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876811 | 0.87 | MAPK14 (0.67) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1876992 | 0.85 | MAPK11 (0.57) | MAPK14MAPK9MAPK10MAPK11NPC1 | |
| SCHEMBL1876030 | 0.85 | MAPK14 (0.75) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1874890 | 0.84 | MAPK14 (0.62) | MAPK14MAPK9MAPK10MAPK11NPC1 | |
| SCHEMBL4337249 | 0.83 | MAPK14 (0.67) | MAPK14MLYCDPTGS2HSP90AA1PTGS1 | |
| SCHEMBL1876999 | 0.82 | MAPK14 (0.75) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1877201 | 0.82 | MAPK14 (0.75) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1877377 | 0.82 | MAPK14 (1.00) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1878819 | 0.82 | MAPK14 (0.75) | MAPK14MAPK9MAPK10MAPK11MLYCD | |
| SCHEMBL1878049 | 0.82 | MAPK14 (0.74) | MAPK14MAPK9MAPK10MAPK11MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832584-B1 | PYRIMIDINYLISOXAZOLE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-7939536-B2 | 5-[(2-chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole; p 38MAP kinase inhibitor; tumor necrosis factor, interleukin, or cyclooxygenase-II related diseases; antiinflammatory, anticarcinogenic, antidiabetic agent | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2011-05-10 | — | — | US | disclosed |
| US-20080114003-A1 | Pyrimidinylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-15 | — | — | US | disclosed |
| EP-1832584-A1 | PYRIMIDINYLISOXAZOL DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2007-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114003-A1 | Pyrimidinylisoxazole Derivatives | MAPK3, MAPK7, MAP3K7 | MAPK14 29/4885MAPK9 20/4885MAPK10 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.