Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 11/20 | 0.53 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824744 | 0.96 | ATM (0.49) | ATMMTORPIK3CAWDR5MCHR1 | |
| SCHEMBL17241367 | 0.86 | ATM (0.43) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824753 | 0.83 | ATM (0.63) | ATMMTORPIK3CAWDR5MCHR1 | |
| SCHEMBL17241453 | 0.82 | ATM (0.63) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241437 | 0.82 | ATM (0.63) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824749 | 0.81 | ATM (0.50) | ATMMTORPIK3CAMCHR1ATR | |
| SCHEMBL18824950 | 0.81 | ATM (0.48) | ATMMTORPIK3CAMCHR1ATR | |
| SCHEMBL18824775 | 0.80 | ATM (0.52) | ATMMTORPIK3CAKCNH2 | |
| SCHEMBL17241650 | 0.80 | ATM (0.63) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824901 | 0.77 | ATM (0.69) | ATMMTORPIK3CAKCNH2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |