Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 19/20 | 1.00 |
| ▸ | ATR | Q13535 | 5/20 | 1.00 |
| ▸ | MTOR | P42345 | 12/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.62 |
| ▸ | PRKDC | P78527 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824891 | 1.00 | ATM (1.00) | ATMATRMTORPIK3CAPIK3CD | |
| SCHEMBL20550138 | 1.00 | ATM (1.00) | ATMATRMTORPIK3CAPIK3CD | |
| SCHEMBL18844676 | 1.00 | ATM (1.00) | ATMATRMTORPIK3CAPIK3CD | |
| SCHEMBL18824833 | 1.00 | ATM (1.00) | ATMATRMTORPIK3CAPIK3CD | |
| SCHEMBL18844636 | 0.96 | ATM (0.92) | ATMATRMTORPIK3CA | |
| SCHEMBL18824921 | 0.95 | ATM (0.91) | ATMATRMTORPIK3CA | |
| SCHEMBL18824925 | 0.95 | ATM (0.91) | ATMATRMTORPIK3CA | |
| SCHEMBL18824922 | 0.95 | ATM (0.91) | ATMATRMTORPIK3CA | |
| SCHEMBL18844682 | 0.95 | ATM (0.91) | ATMATRMTORPIK3CA | |
| SCHEMBL20550164 | 0.95 | ATM (0.91) | ATMATRMTORPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |