Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 5/20 | 0.55 |
| ▸ | CHUK | O15111 | 13/20 | 0.48 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205666 | 0.88 | TTBK1 (0.51) | TTBK1CHUKMAP3K14 | |
| SCHEMBL17585403 | 0.87 | CHUK (0.62) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205470 | 0.87 | TTBK1 (0.61) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205628 | 0.87 | TTBK1 (0.55) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205474 | 0.85 | TTBK1 (0.63) | TTBK1CHUK | |
| SCHEMBL16205451 | 0.85 | CHUK (0.65) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205669 | 0.85 | TTBK1 (0.62) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205478 | 0.84 | TTBK1 (0.62) | TTBK1CHUK | |
| SCHEMBL16205643 | 0.83 | TTBK1 (0.60) | TTBK1CHUKMAP3K14 | |
| SCHEMBL16205469 | 0.83 | CHUK (0.64) | TTBK1CHUKMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643964-B2 | 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the treatment of cancer | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-09 | — | — | US | disclosed |