Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890113 | 0.98 | CHEK2 (0.36) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12661209 | 0.94 | CHEK2 (0.34) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL933197 | 0.93 | USP30 (0.32) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL933194 | 0.93 | USP30 (0.32) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1044322 | 0.93 | CHEK2 (0.35) | CHEK2F11L3MBTL1GPR119MEN1 | |
| SCHEMBL1887080 | 0.90 | CHEK2 (0.36) | CHEK2F11L3MBTL1GPR119MEN1 | |
| SCHEMBL1890115 | 0.90 | CHEK2 (0.32) | CHEK2GPR119 | |
| SCHEMBL934276 | 0.90 | CHEK2 (0.36) | CHEK2F11L3MBTL1GPR119MEN1 | |
| SCHEMBL12661134 | 0.87 | CHEK2 (0.38) | CHEK2F11L3MBTL1GPR119MEN1 | |
| SCHEMBL933077 | 0.86 | USP30 (0.32) | CHEK2GPR119KMT2AJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112100-A1 | Hepatitis C Virus Inhibitors | PFIZER INC. | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112100-A1 | Hepatitis C Virus Inhibitors | HAVCR2, SLC10A1, HCCS | CHEK2 3724/4885PIK3CD 1645/4885PIK3CA 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.