Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 12/20 | 0.80 |
| ▸ | GSK3A | P49840 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.57 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16012783 | 1.00 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012188 | 1.00 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012675 | 1.00 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL18830109 | 0.93 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012471 | 0.93 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012026 | 0.93 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16014934 | 0.92 | MAPK6 (0.91) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012120 | 0.92 | MAPK6 (0.91) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012454 | 0.92 | MAPK6 (0.91) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16012342 | 0.91 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |