Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 12/20 | 0.55 |
| ▸ | GSK3A | P49840 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16022062 | 0.89 | GSK3A (0.61) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| SCHEMBL17435261 | 0.89 | GSK3A (0.61) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| SCHEMBL16012023 | 0.85 | MAPK6 (0.63) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL16012464 | 0.85 | MAPK6 (0.63) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL16022095 | 0.81 | MAPK6 (0.80) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16022031 | 0.74 | MAPK6 (0.64) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| SCHEMBL17435275 | 0.74 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL17435287 | 0.74 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012659 | 0.74 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16014900 | 0.74 | MAPK6 (0.68) | MAPK6GSK3AGSK3BEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |