Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.52 |
| ▸ | EIF2AK4 | Q9P2K8 | 8/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL18813060 | 0.95 | GSK3A (0.57) | GSK3AGSK3BMAPK6EIF2AK4 | |
| Carbamic Acid SCHEMBL18813026 | 0.94 | GSK3A (0.56) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16022124 | 0.91 | MAPK6 (0.65) | GSK3AGSK3BMAPK6EIF2AK4CCNE1 | |
| SCHEMBL16012398 | 0.91 | MAPK6 (0.65) | GSK3AGSK3BMAPK6EIF2AK4CCNE1 | |
| SCHEMBL16012090 | 0.87 | GSK3A (0.63) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16022137 | 0.87 | GSK3A (0.50) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16022186 | 0.87 | MAPK6 (0.66) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16012089 | 0.87 | GSK3A (0.63) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL18830215 | 0.87 | GSK3A (0.63) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16012091 | 0.87 | GSK3A (0.63) | GSK3AGSK3BMAPK6EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |