Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.36 |
| ▸ | KDM5C | P41229 | 7/20 | 0.36 |
| ▸ | KDM5A | P29375 | 5/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 3/20 | 0.34 |
| ▸ | KDM4B | O94953 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17984985 | 0.89 | KDM5B (0.38) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL18860202 | 0.86 | KDM5B (0.36) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16305524 | 0.86 | KDM5B (0.36) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16006920 | 0.86 | KDM5B (0.34) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16305495 | 0.85 | KDM5B (0.43) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16303320 | 0.81 | KDM4E (0.40) | — | |
| SCHEMBL15995309 | 0.81 | KDM4E (0.40) | — | |
| SCHEMBL16293002 | 0.81 | KDM5B (0.43) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16293837 | 0.80 | KDM5B (0.37) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16293836 | 0.80 | KDM5B (0.37) | KDM5BKDM5CKDM5AKDM4CKDM5D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650339-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-05-16 | — | — | US | disclosed |