Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.57 |
| ▸ | TTK | P33981 | 2/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17410930 | 0.85 | PTK2 (0.78) | IGF1RPTK2ALKMAP4K1EGFR | |
| SCHEMBL11919325 | 0.78 | PTK2 (0.84) | IGF1RPTK2ALKMAP4K1EGFR | |
| SCHEMBL30372123 | 0.77 | MAP4K1 (0.72) | IGF1RPTK2ALKTTKMAP4K1 | |
| SCHEMBL16998990 | 0.76 | PTK2 (0.80) | IGF1RPTK2ALKMAP4K1EGFR | |
| SCHEMBL11919345 | 0.74 | PTK2 (0.77) | IGF1RPTK2ALKMAP4K1EGFR | |
| SCHEMBL12429284 | 0.74 | IGF1R (0.85) | IGF1RPTK2ALKINSRMAPK8 | |
| SCHEMBL11919322 | 0.74 | PTK2 (0.83) | IGF1RPTK2ALKTTKMAP4K1 | |
| SCHEMBL16998993 | 0.73 | PTK2 (0.65) | IGF1RPTK2ALKEGFRJAK3 | |
| SCHEMBL22518901 | 0.73 | EGFR (0.75) | IGF1RPTK2ALKTTKEGFR | |
| SCHEMBL11919218 | 0.73 | PTK2 (0.81) | IGF1RPTK2ALKTTKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165530-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | Qilu Pharmaceutical Co., Ltd (CN) | 2017-05-10 | — | — | EP | disclosed |