Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | IL17A | Q16552 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926346 | 0.86 | CHEK2 (0.41) | ACHECHEK2FGFR1FLT1RUNX1 | |
| Hydrochloric Acid SCHEMBL4126862 | 0.85 | CHEK2 (0.40) | ACHECHEK2FGFR1FLT1RUNX1 | |
| SCHEMBL4133817 | 0.85 | SYK (0.50) | ACHECHEK2FGFR1FLT1KDR | |
| Trifluoroacetic Acid SCHEMBL4129766 | 0.81 | SYK (0.46) | ACHECHEK2RUNX1TBK1KDR | |
| SCHEMBL4142555 | 0.81 | SYK (0.49) | ACHECHEK2FGFR1FLT1HRH4 | |
| SCHEMBL18832926 | 0.81 | HRH4 (0.37) | ACHECHEK2HRH4 | |
| Hydrochloric Acid SCHEMBL4134722 | 0.80 | SYK (0.49) | CHEK2FGFR1FLT1HRH4KDR | |
| SCHEMBL3924905 | 0.78 | CHEK2 (0.39) | CHEK2FGFR1FLT1KDR | |
| SCHEMBL4133840 | 0.77 | SYK (0.53) | ACHECHEK2FGFR1FLT1HRH4 | |
| SCHEMBL13373931 | 0.76 | SYK (0.45) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-B1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2017-05-10 | — | — | EP | disclosed |