Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373931 | 0.91 | SYK (0.45) | SYKITKPDE5AKMT2ACYP3A4 | |
| SCHEMBL3926980 | 0.91 | SYK (0.37) | SYKITKPDE5AKMT2ACYP3A4 | |
| SCHEMBL3928004 | 0.90 | SYK (0.36) | SYKITKPDE5AKMT2ACYP3A4 | |
| SCHEMBL3926346 | 0.89 | CHEK2 (0.41) | SYKITKKMT2AFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL4126862 | 0.88 | CHEK2 (0.40) | SYKITKKMT2AFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL4145377 | 0.86 | SYK (0.34) | SYKITKPDE5AKMT2ACYP3A4 | |
| SCHEMBL3924905 | 0.86 | CHEK2 (0.39) | SYKITKPDE5AKMT2ACYP3A4 | |
| SCHEMBL3923205 | 0.85 | HRH4 (0.37) | SYKITKMAPTHRH4PDE3B | |
| SCHEMBL5952616 | 0.85 | SYK (0.44) | SYKITKHSD17B10MAPTTP53 | |
| SCHEMBL3926161 | 0.85 | SYK (0.36) | SYKITKHSD17B10MAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-B1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2017-05-10 | — | — | EP | disclosed |