Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | ILK | Q13418 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121801 | 0.88 | SYK (0.53) | SYKITKCHEK2HRH4KDM4E | |
| SCHEMBL4122016 | 0.84 | SYK (0.47) | SYKITKCHEK2HRH4ATM | |
| Trifluoroacetic Acid SCHEMBL4134146 | 0.84 | SYK (0.49) | SYKITKCHEK2HRH4KDM4E | |
| SCHEMBL4121774 | 0.84 | SYK (0.41) | SYKITKCHEK2HRH4ATM | |
| SCHEMBL18832926 | 0.83 | HRH4 (0.37) | SYKITKCHEK2HRH4ROCK2 | |
| SCHEMBL4002962 | 0.82 | SYK (0.43) | SYKITKCHEK2HRH4ATM | |
| SCHEMBL4126777 | 0.82 | SYK (0.42) | SYKITKCHEK2HRH4KDM4E | |
| SCHEMBL4124795 | 0.81 | SYK (0.38) | SYKITKCHEK2HRH4KDM4E | |
| SCHEMBL3935250 | 0.81 | SYK (0.38) | SYKITKCHEK2HRH4KDM4E | |
| SCHEMBL4126476 | 0.81 | ITK (0.43) | SYKITKCHEK2HRH4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-B1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2017-05-10 | — | — | EP | disclosed |