Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 20/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.61 |
| ▸ | EIF4E | P06730 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18839818 | 0.99 | MKNK2 (0.60) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838904 | 0.91 | MKNK2 (0.53) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838548 | 0.91 | MKNK2 (0.58) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838753 | 0.91 | MKNK2 (0.62) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838790 | 0.90 | MKNK2 (0.61) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838786 | 0.90 | MKNK2 (0.50) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838989 | 0.89 | MKNK2 (0.58) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838537 | 0.89 | MKNK2 (0.60) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838782 | 0.88 | MKNK2 (0.47) | MKNK2MKNK1EIF4E | |
| SCHEMBL18838585 | 0.88 | MKNK2 (0.59) | MKNK2MKNK1EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917185-B1 | SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS | EVOTEC INT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |