Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.69 |
| ▸ | ROS1 | P08922 | 1/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18843557 | 0.95 | ALK (0.77) | ALKROS1PTK2 | |
| SCHEMBL18843544 | 0.88 | ALK (0.77) | ALKROS1PTK2INSRKCNH2 | |
| SCHEMBL22166560 | 0.86 | ALK (0.70) | ALKINSRKCNH2 | |
| SCHEMBL18843597 | 0.82 | ALK (1.00) | ALKROS1PTK2INSR | |
| SCHEMBL18843556 | 0.82 | ALK (1.00) | ALKROS1PTK2INSRKCNH2 | |
| SCHEMBL22166557 | 0.81 | ALK (0.79) | ALK | |
| SCHEMBL28427764 | 0.80 | ALK (0.67) | ALKINSRKCNH2 | |
| SCHEMBL18843547 | 0.77 | ALK (1.00) | ALKINSR | |
| SCHEMBL22566704 | 0.76 | ALK (0.61) | ALKROS1PTK2INSRKCNH2 | |
| SCHEMBL21050561 | 0.76 | ALK (0.88) | ALKROS1PTK2INSRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695347-B2 | Pyrimidine derivative and use thereof | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-06-30 | — | — | US | disclosed |
| WO-2017076355-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | 湖北生物医药产业技术研究院有限公司 | 2017-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695347-B2 | Pyrimidine derivative and use thereof | ALK, DPYD, TYMP | ALK 1/4885ROS1 88/4885PTK2 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.