Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 13/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15456467 | 0.85 | CYP3A4 (0.66) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL15456402 | 0.85 | CYP2C9 (0.52) | CYP3A4CYP2C9CYP2C19CSF1R | |
| SCHEMBL15455792 | 0.83 | CYP2C19 (0.56) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL1266441 | 0.81 | CYP3A4 (0.79) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL1891900 | 0.81 | CYP2C9 (0.79) | CYP3A4CYP2C9CYP2C19CSF1RCYP2D6 | |
| SCHEMBL15456704 | 0.80 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL15456371 | 0.78 | CYP3A4 (0.64) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL15456432 | 0.78 | CYP3A4 (0.67) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL15456729 | 0.77 | CYP2C9 (0.63) | CYP3A4CYP2C9CYP2C19CSF1RKIT | |
| SCHEMBL15456302 | 0.76 | CYP3A4 (0.56) | CYP3A4CYP2C9CYP2C19CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096593-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140045840-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-20110112127-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112127-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, FLT3, BRAF | CYP3A4 3717/4885CYP2C9 3884/4885CYP2C19 4018/4885 |
| US-20140045840-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, FLT3, BRAF | CYP3A4 3717/4885CYP2C9 3884/4885CYP2C19 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.