Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241425 | 1.00 | RXFP1 (0.61) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL17245575 | 1.00 | RXFP1 (0.61) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL18844648 | 0.94 | RXFP1 (0.59) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL17246440 | 0.94 | RXFP1 (0.59) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL17272518 | 0.94 | RXFP1 (0.59) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL17241445 | 0.94 | RXFP1 (0.66) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL18843741 | 0.92 | MAPK1 (0.65) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL18843746 | 0.87 | MAPK1 (0.66) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL17272569 | 0.87 | MAPK1 (0.66) | RXFP1MAPK1GAANPSR1PDE4B | |
| SCHEMBL529812 | 0.85 | MAPK1 (0.64) | RXFP1MAPK1GAANPSR1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |