Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18789280 | 0.83 | NPSR1 (0.35) | NPSR1MAPTLMNAPOLBMEN1 | |
| SCHEMBL1469083 | 0.82 | — | — | |
| SCHEMBL18789232 | 0.82 | NPSR1 (0.34) | NPSR1MAPTLMNA | |
| SCHEMBL21070704 | 0.81 | NPSR1 (0.32) | NPSR1EPHX1MAPT | |
| SCHEMBL23904378 | 0.81 | CYP2C19 (0.34) | NPSR1LMNAGAACYP2C9CYP2C19 | |
| SCHEMBL4870839 | 0.78 | NPSR1 (0.38) | NPSR1EPHX1MAPTLMNAPOLB | |
| SCHEMBL2775123 | 0.78 | NPSR1 (0.50) | NPSR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25228494 | 0.78 | NPSR1 (0.45) | NPSR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL23888104 | 0.77 | NPSR1 (0.32) | NPSR1MAPT | |
| SCHEMBL1472063 | 0.77 | FFAR3 (0.37) | NPSR1EPHX1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371171-B1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORP (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2017079140-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION (US) | 2017-05-11 | — | — | WO | disclosed |