Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 17/20 | 0.79 |
| ▸ | CLK3 | P49761 | 17/20 | 0.79 |
| ▸ | DYRK1A | Q13627 | 17/20 | 0.79 |
| ▸ | CLK1 | P49759 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.62 |
| ▸ | WNT1 | P04628 | 3/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15306703 | 0.93 | CLK2 (0.86) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL18850305 | 0.91 | CLK2 (0.76) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL18850265 | 0.91 | CLK2 (0.76) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL12010076 | 0.90 | CLK2 (0.91) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL1270801 | 0.89 | CLK2 (1.00) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL15868986 | 0.88 | CLK2 (0.76) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL18850376 | 0.87 | CLK2 (0.71) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL15306583 | 0.87 | CLK2 (0.84) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL15306594 | 0.86 | CLK2 (0.84) | CLK2CLK3DYRK1ACLK1GSK3B | |
| SCHEMBL18850377 | 0.85 | CLK2 (0.73) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079759-A1 | 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF | SAMUMED, LLC (US) | 2017-05-11 | — | — | WO | disclosed |