SCHEMBL1885262

SCHEMBL1885262

[CH2]CCCSC(C)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2289375 0.92
SCHEMBL6843334 0.90 CYP2C19 (0.43)
SCHEMBL6843354 0.90 CYP2C19 (0.43)
SCHEMBL25281666 0.90 CYP2C19 (0.43)
SCHEMBL12506492 0.90 CYP2C19 (0.43)
SCHEMBL1879803 0.83
SCHEMBL7908937 0.83 CYP2C19 (0.55)
SCHEMBL27822244 0.83 CYP2C19 (0.55)
SCHEMBL14478080 0.80 CYP2C19 (0.52)
SCHEMBL6871500 0.80 CYP2C19 (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2192109-B1 BICYCLIC -AMINO ACID DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2013-09-04 EP disclosed
US-7947738-B2 Bicyclic γ-amino acid derivative DAIICHI SANKYO COMPANY, LTD. (JP) 2011-05-24 US disclosed
US-20100249229-A1 BICYCLIC gamma-AMINO ACID DERIVATIVE DAIICHI SANKYO COMPANY, LTD. (JP) 2010-09-30 US disclosed
EP-2192109-A1 BICYCLIC -AMINO ACID DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2010-06-02 EP disclosed
EP-1829876-A1 NITROGENEOUS TRICYCLIC COMPOUND Asahi Kasei Pharma Corporation (JP) 2007-09-05 EP disclosed
US-20060247266-A1 Nitrogen-containing tricyclic compounds ASAHI KASEI PHARMA CORPORATION (JP) 2006-11-02 US disclosed
US-6900282-B2 Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2005-05-31 US disclosed
US-6890998-B2 Thiol activation of polyurethanes and methods of making the same THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2005-05-10 US disclosed
US-20040102598-A1 Novel thiol activation of polyurethanes and methods of making the same NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-05-27 US disclosed
US-20040092698-A1 Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-05-13 US disclosed
WO-2004029581-A2 METHOD OF DETERMINING SURFACE BINDING CAPACITY THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2004-04-08 WO disclosed
WO-2004029124-A1 NOVEL THIOL ACTIVATION OF POLYURETHANES AND METHODS OF MAKING THE SAME THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2004-04-08 WO disclosed
US-20040063158-A1 Method of determining surface binding capacity NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-04-01 US disclosed
US-5990328-A FORMING 4-NITRO-3-KETOSTEROIDS WHICH BY NITRATION OF THE CORRESPONDING 3,5-DIENOLATE, REDUCTION OF 4-NITRO-3-KETOSTEROID FORMS 4-AMINO-3-KETOSTEROID MERRELL PHARMACEUTICALS INC. (US) 1999-11-23 US disclosed
US-5965550-A INHIBITING STEROID C17-20 LYASE BY ADMINISTERING A 4-NITRO STEROID INHIBITORY COMPOUND OF GIVEN FORMULA, SUCH AS 17B-CYCLOPROPYLOXY-4-NITROANDROST-4-EN-3-ONE; INHIBITS FORMATION OF BOTH ANDROGENIC AND ESTROGENIC STEROIDS MERRELL PHARMACEUTICALS INC. (US) 1999-10-12 US disclosed
US-5869475-A Certain 3-ketosteroids used to inhibit steroid 5α-reductase MERRELL PHARMACEUTICALS, INC. (US) 1999-02-09 US disclosed
EP-0758340-B1 PROCESS FOR THE PREPARATION OF 4-AMINO-DELTA 4-3-KETOSTEROIDS VIA 4-NITRO-DELTA 4-3-KETOSTEROIDS MERRELL PHARMA INC (US) 1999-01-07 EP disclosed
US-5750744-A ENZYME INHIBITORS MERRELL PHARMACEUTICALS INC. (US) 1998-05-12 US disclosed
EP-0758340-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-DELTA 4-3-KETOSTEROIDS VIA 4-NITRO-DELTA 4-3-KETOSTEROIDS MERRELL PHARMACEUTICALS INC. (US) 1997-02-19 EP disclosed
WO-1995029932-A1 PROCESS FOR THE PREPARATION OF 4-AMINO-Δ4-3-KETOSTEROIDS VIA 4-NITRO-Δ4-3-KETOSTEROIDS MERRELL PHARMACEUTICALS INC. (US) 1995-11-09 WO disclosed