Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.84 |
| ▸ | JAK3 | P52333 | 8/20 | 0.84 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.84 |
| ▸ | AURKA | O14965 | 2/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.84 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.84 |
| ▸ | PLK4 | O00444 | 1/20 | 0.84 |
| ▸ | STK10 | O94804 | 1/20 | 0.84 |
| ▸ | PAK4 | O96013 | 1/20 | 0.84 |
| ▸ | RET | P07949 | 1/20 | 0.84 |
| ▸ | FER | P16591 | 1/20 | 0.84 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.84 |
| ▸ | JAK1 | P23458 | 1/20 | 0.84 |
| ▸ | TYK2 | P29597 | 1/20 | 0.84 |
| ▸ | FLT3 | P36888 | 1/20 | 0.84 |
| ▸ | STAT3 | P40763 | 1/20 | 0.84 |
| ▸ | STAT5A | P42229 | 1/20 | 0.84 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.84 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.84 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-1480 SCHEMBL29523565 | 0.91 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| Azd-1480 SCHEMBL220400 | 0.91 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| Azd-1480 SCHEMBL219103 | 0.91 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| Azd-1480 SCHEMBL3345019 | 0.91 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL3343484 | 0.84 | JAK2 (0.67) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL4076083 | 0.82 | NTRK1 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL3033142 | 0.80 | NTRK1 (0.78) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL3335945 | 0.80 | NTRK1 (0.72) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL218888 | 0.80 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL217992 | 0.80 | JAK2 (1.00) | JAK2JAK3NTRK1AURKAFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180207154-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor and/or a JAK-2 Inhibitor | ACERTA PHARMA BV (NL) | 2018-07-26 | — | — | US | disclosed |
| US-9949971-B2 | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor | ACERTA PHARMA B.V. (NL) | 2018-04-24 | — | — | US | disclosed |
| US-20170136014-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor and/or a JAK-2 Inhibitor | ACERTA PHARMA BV (NL) | 2017-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170136014-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor and/or a JAK-2 Inhibitor | BTK, JAK2, JAK1 | JAK2 2/4885JAK3 4/4885NTRK1 4136/4885 |
| US-20180207154-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor and/or a JAK-2 Inhibitor | BTK, JAK2, JAK1 | JAK2 2/4885JAK3 5/4885NTRK1 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.