Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018752 | 0.80 | NOTUM (0.53) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL6879933 | 0.78 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL4341894 | 0.76 | NOTUM (0.78) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL15648532 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL11827747 | 0.75 | NOTUM (0.51) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL6850955 | 0.75 | KDM4E (0.64) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL6852527 | 0.75 | NOTUM (0.55) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL3118178 | 0.74 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL22964275 | 0.74 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL45348 | 0.74 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |
| EP-3560920-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | Janssen Pharmaceutica NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| EP-2909192-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-17 | — | — | EP | disclosed |