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SCHEMBL1885690

SCHEMBL1885690

CCOC(=O)n1nc2c(c1NC(=O)c1ccc(N3CCN(C)CC3)cc1NC(=O)c1ccn(S(=O)(=O)c3ccc(C)cc3)c1)CN(S(=O)(=O)c1cc(F)cc(F)c1)CC2(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 5/20 0.43
▸ USP2 O75604 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ INSR P06213 6/20 0.34
▸ ALK Q9UM73 6/20 0.34
▸ AURKA O14965 1/20 0.33
▸ AURKB Q96GD4 1/20 0.33
▸ NTRK1 P04629 2/20 0.33
▸ NTRK3 Q16288 2/20 0.33
▸ NTRK2 Q16620 2/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ HTT P42858 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ PTGDR Q13258 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1891793 0.85 IGF1R (0.51) IGF1RUSP2HSD17B10TP53CYP1A2
SCHEMBL1887045 0.84 IGF1R (0.43) IGF1RUSP2INSRALKAURKA
Hydrochloric Acid SCHEMBL1887042 0.83 IGF1R (0.42) IGF1RUSP2INSRALKAURKA
SCHEMBL1893236 0.83 IGF1R (0.41) IGF1RINSRALKMEN1KMT2A
SCHEMBL1372191 0.80 HSD17B10 (0.35) IGF1RUSP2HSD17B10TP53CYP1A2
SCHEMBL1374766 0.79 IGF1R (0.33) IGF1RUSP2HSD17B10TP53CYP1A2
SCHEMBL1885436 0.79 IGF1R (0.38) IGF1RUSP2HSD17B10INSRALK
SCHEMBL1905013 0.78 IGF1R (0.41) IGF1RUSP2HSD17B10TP53CYP1A2
SCHEMBL1891377 0.77 MAPT (0.38) IGF1RHSD17B10TP53MEN1KMT2A
SCHEMBL4279723 0.75 IGF1R (0.40) IGF1RINSRALKAURKAAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885USP2 3382/4885HSD17B10 4006/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885USP2 3382/4885HSD17B10 4006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.