Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 19/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17292958 | 0.90 | MALT1 (0.47) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL17293012 | 0.85 | MALT1 (0.55) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL18787643 | 0.85 | KDM4E (0.43) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL17293010 | 0.85 | MALT1 (0.55) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL18787821 | 0.85 | MALT1 (0.55) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL18787657 | 0.83 | MALT1 (0.52) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL19826558 | 0.83 | KDM4E (0.41) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL17293051 | 0.83 | MALT1 (0.52) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL17293052 | 0.83 | MALT1 (0.52) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL18787621 | 0.83 | TP53 (0.43) | KDM4ENPC1LMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017081641-A1 | NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2017-05-18 | — | — | WO | disclosed |