Known targets — ChEMBL curated mechanism
BRAFFLT1FLT3FLT4KDRKITPDGFRBRAF1RET
The experimentally established mechanism targets of Sorafenib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 known ✓ | P04049 | 12/20 | 0.98 |
| ▸ | KDR known ✓ | P35968 | 6/20 | 0.98 |
| ▸ | BRAF known ✓ | P15056 | 4/20 | 0.98 |
| ▸ | RET known ✓ | P07949 | 3/20 | 0.98 |
| ▸ | PDGFRB known ✓ | P09619 | 2/20 | 0.98 |
| ▸ | KIT known ✓ | P10721 | 2/20 | 0.98 |
| ▸ | FLT1 known ✓ | P17948 | 2/20 | 0.98 |
| ▸ | FLT4 known ✓ | P35916 | 2/20 | 0.98 |
| ▸ | FLT3 known ✓ | P36888 | 2/20 | 0.98 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.98 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.98 |
| ▸ | ABL1 | P00519 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 2/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.98 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.98 |
| ▸ | MAOA | P21397 | 2/20 | 0.98 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorafenib SCHEMBL28894639 | 1.00 | RAF1 (0.98) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL16539296 | 0.99 | RAF1 (0.96) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL16539295 | 0.99 | RAF1 (0.96) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL1702117 | 0.99 | RAF1 (0.96) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL1701746 | 0.99 | RAF1 (0.96) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL8218 | 0.99 | RAF1 (1.00) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL14739751 | 0.99 | RAF1 (1.00) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL29349634 | 0.99 | RAF1 (1.00) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL1896610 | 0.98 | RAF1 (0.98) | RAF1KDRBRAFRETEPHX2 | |
| Sorafenib SCHEMBL1533982 | 0.98 | RAF1 (0.98) | RAF1KDRBRAFRETEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181127-B1 | SORAFENIB PHARMACEUTICAL COMPOSITION | XSPRAY PHARMA AB PUBL (SE) | 2023-03-08 | — | — | EP | claimed |
| US-10314829-B2 | Pharmaceutical compositions | XSPRAY MICROPARTICLES AB (SE) | 2019-06-11 | — | — | US | claimed |
| US-20190076413-A1 | PHARMACEUTICAL COMPOSITIONS | XSPRAY MICROPARTICLES AB (SE) | 2019-03-14 | — | — | US | claimed |
| US-9833443-B2 | Pharmaceutical compositions | XSPRAY MICROPARTICLES AB (SE) | 2017-12-05 | — | — | US | claimed |
| US-20170143683-A1 | PHARMACEUTICAL COMPOSITIONS | XSPRAY MICROPARTICLES AB (SE) | 2017-05-25 | — | — | US | claimed |
| EP-3181127-B1 | SORAFENIB PHARMACEUTICAL COMPOSITION | XSPRAY PHARMA AB PUBL (SE) | 2023-03-08 | — | — | EP | disclosed |
| CN-115397517-A | FLT 3-Targeted chimeric antigen receptor-modified cells for the treatment of FLT 3-positive malignancies | 希望之城 | 2022-11-25 | — | — | CN | disclosed |