SCHEMBL18868360

SCHEMBL18868360

c1ccc(-n2c3cc4c(cc3c3c5c(ccc32)sc2ccccc25)c2ccccc2n4-c2ccc3ccccc3c2)cc1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PMM2 O15305 1/20 0.35
MPI P34949 1/20 0.35
PHOSPHO1 Q8TCT1 1/20 0.35
HPGD P15428 1/20 0.32
JAK2 O60674 1/20 0.32
JAK3 P52333 1/20 0.32
F2 P00734 1/20 0.32
F10 P00742 1/20 0.32
PRSS1 P07477 1/20 0.32
HSD17B10 Q99714 1/20 0.32
PDE1B Q01064 1/20 0.31
PDE3A Q14432 1/20 0.31
PDE11A Q9HCR9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18868361 0.93 KDM4E (0.37) KDM4EATML3MBTL1PMM2MPI
SCHEMBL19653507 0.93 KDM4E (0.38) KDM4EATML3MBTL1PMM2MPI
SCHEMBL19653717 0.93 KDM4E (0.38) KDM4EATML3MBTL1PMM2MPI
SCHEMBL22011417 0.91 ATM (0.43) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL18119136 0.91 PMM2 (0.39) KDM4EATML3MBTL1PMM2MPI
SCHEMBL18868357 0.91 ATM (0.47) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL18119087 0.89 KDM4E (0.38) KDM4EATML3MBTL1PMM2MPI
SCHEMBL19652838 0.89 KDM4E (0.35) KDM4EATML3MBTL1PMM2MPI
SCHEMBL19653736 0.89 KDM4E (0.35) KDM4EATML3MBTL1PMM2MPI
SCHEMBL23862206 0.89 PMM2 (0.36) KDM4EATML3MBTL1PMM2MPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10319918-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD (KR) 2019-06-11 US disclosed
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-12-07 US disclosed
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-12-07 US disclosed
US-9768394-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2017-09-19 US disclosed
US-9768394-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2017-09-19 US disclosed
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-05-18 US disclosed
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10319918-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same OR10J3, VDAC1, ICOSLG KDM4E 652/4885ATM 1420/4885L3MBTL1 315/4885
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME OR10J3, VDAC1, ICOSLG KDM4E 652/4885ATM 1420/4885L3MBTL1 315/4885
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME OR10J3, VDAC1, ICOSLG KDM4E 652/4885ATM 1420/4885L3MBTL1 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.