Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.41 |
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | TYK2 | P29597 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245556 | 0.86 | JAK2 (0.44) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18869326 | 0.80 | JAK1 (0.37) | JAK1JAK2TYK2JAK3BTK | |
| SCHEMBL16245609 | 0.78 | JAK2 (0.42) | JAK1JAK2TYK2JAK3BTK | |
| SCHEMBL16245580 | 0.76 | RPS6KA3 (0.46) | JAK3BTK | |
| SCHEMBL16246167 | 0.76 | ITK (0.46) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL16245553 | 0.75 | RPS6KA3 (0.45) | JAK3BTK | |
| SCHEMBL16245707 | 0.73 | EIF2AK4 (0.47) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL16245542 | 0.73 | RPS6KA3 (0.52) | JAK3BTK | |
| SCHEMBL16245605 | 0.72 | RPS6KA3 (0.51) | JAK3BTK | |
| SCHEMBL16245576 | 0.72 | EGFR (0.46) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |