SCHEMBL18869280

SCHEMBL18869280

C=CC(=O)Oc1ccc(-c2ccc(OC)c(F)c2F)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.38
TYMS P04818 1/20 0.38
THRB P10828 3/20 0.37
THRA P10827 1/20 0.37
CYP3A4 P08684 2/20 0.36
CYP17A1 P05093 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
PTGS1 P23219 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.35
KDM4E B2RXH2 1/20 0.34
KMT2A Q03164 2/20 0.33
GRM8 O00222 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
TACR1 P25103 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9607890 0.92 TYMS (0.42) EGFRTYMSTHRBTHRACYP3A4
SCHEMBL17750818 0.86 TYMS (0.37) EGFRTYMSTHRBTHRA
SCHEMBL19497335 0.86 ERN1 (0.41) EGFRTHRBLMNAMAPK1HTT
SCHEMBL21417666 0.85 AR (0.41) EGFRPTGS1LMNAMAPK1HTT
SCHEMBL18472427 0.85 ERN1 (0.43) THRBCYP17A1CYP11B1CYP11B2LMNA
SCHEMBL19882317 0.85 AR (0.44) PTGS1LMNAMAPK1HTTRAB9A
SCHEMBL22600378 0.85 TYMS (0.36) EGFRTYMSTHRBTHRAKMT2A
SCHEMBL13986530 0.85 TYMS (0.43) EGFRTYMSTHRBTHRACYP3A4
SCHEMBL17794355 0.84 TYMS (0.38) TYMSTHRBTHRAMAOAMAOB
SCHEMBL18436412 0.84 BACE1 (0.44) THRBLMNAKDM4ECYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3551723-B1 ADDITIVES FOR LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 2023-09-20 EP disclosed
EP-3628721-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-03-01 EP disclosed
EP-3944011-A1 LIQUID-CRYSTAL DISPLAY Merck Patent GmbH (DE) 2022-01-26 EP disclosed
EP-3257916-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-11-17 EP disclosed
EP-3688118-B1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2021-05-19 EP disclosed
EP-3521401-B1 COMPOUNDS FOR HOMEOTROPIC ALIGNMENT OF LIQUID CRYSTALINE MEDIA MERCK PATENT GMBH (DE) 2021-04-21 EP disclosed
EP-3757192-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2020-12-30 EP disclosed
EP-3730590-A1 LIQUID CRYSTAL MEDIA WITH HOMEOTROPIC ALIGNMENT Merck Patent GmbH (DE) 2020-10-28 EP disclosed
EP-3730591-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2020-10-28 EP disclosed
EP-3502209-B1 LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT MERCK PATENT GMBH (DE) 2020-10-14 EP disclosed
EP-3502209-A1 LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT Merck Patent GmbH (DE) 2019-06-26 EP disclosed
EP-2725083-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2019-03-27 EP disclosed
EP-3298105-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-03-20 EP disclosed
EP-3428246-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-01-16 EP disclosed
EP-3083883-B1 METHOD FOR CLEANING A LIQUID CRYSTAL MIXTURE MERCK PATENT GMBH (DE) 2018-07-11 EP disclosed
EP-2703472-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2018-07-04 EP disclosed
EP-3323872-A1 COMPOUNDS FOR HOMOTROPIC ALIGNMENT OF LIQUID CRYSTAL MEDIA Merck Patent GmbH (DE) 2018-05-23 EP disclosed
EP-3083408-B1 FILLING DEVICE AND USE THEREOF FOR FILLING A FLUID MERCK PATENT GMBH (DE) 2018-02-21 EP disclosed
EP-2855628-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2017-09-06 EP disclosed
EP-2628779-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-05-17 EP disclosed