Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCND2 | P30279 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264903 | 0.81 | RPS6KA3 (0.47) | JAK3BTKRPS6KA3FGFR1FLT3 | |
| SCHEMBL18869084 | 0.79 | RPS6KA3 (0.49) | JAK3BTKRPS6KA3SRCLCK | |
| SCHEMBL17827723 | 0.75 | RPS6KA3 (0.51) | JAK3BTKRPS6KA3SRCWEE1 | |
| SCHEMBL16245539 | 0.75 | ITK (0.47) | JAK3BTKRPS6KA3SRCWEE1 | |
| Hydrochloric Acid SCHEMBL16245564 | 0.74 | RPS6KA3 (0.50) | JAK3BTKRPS6KA3SRCWEE1 | |
| SCHEMBL16245553 | 0.74 | RPS6KA3 (0.45) | JAK3BTKRPS6KA3SRCFGFR1 | |
| SCHEMBL17827722 | 0.74 | RPS6KA3 (0.52) | JAK3BTKRPS6KA3SRCWEE1 | |
| SCHEMBL16264888 | 0.74 | ITK (0.48) | JAK3BTKRPS6KA3SRCWEE1 | |
| Hydrochloric Acid SCHEMBL16245574 | 0.73 | RPS6KA3 (0.51) | JAK3BTKRPS6KA3SRCWEE1 | |
| SCHEMBL16245580 | 0.73 | RPS6KA3 (0.46) | JAK3BTKRPS6KA3SRCFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |